業績

(1) Seino M, Okada M, Shibuya K, Seino S, Suzuki S, Takeda H, Ohta T, Kurachi H, Kitanaka C. Differential contribution of ROS to resveratrol-induced cell death and loss of self-renewal capacity of ovarian cancer stem cells. Anticancer Res. 2015;35(1):85-96

(2) Hasegawa A, Takahashi T, Igarashi H, Amita M, Matsukawa J, Nagase S. Predictive factors for oocyte retrieval failure in controlled ovarian hyperstimulation protocols: a retrospective observational cohort study. Reprod Biol Endocrinol 2015;13:53

(3) Hasegawa A, Igarashi H, Ohta T, Kurachi H, Takahashi K. Three-dimensional computed tomography of pelvic masses in mayer-rokitansky-kuster-hauser syndrome. Obstet Gynecol. 2015;123(2):393-396

(4) Igarashi H, Takahashi T, Nagase S. Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies. Reprod Med Biol. 2015;14:159-169

(5) Sakaki H, Okada M, Kuramoto K, Takeda H, Watarai H, Suzuki S, Seino S, Seino M, Ohta T, Nagase S, Kurachi H, Kitanaka C. GSKJ4, A Selective Jumonji H3K27 Demethylase Inhibitor, Effectively Targets Ovarian Cancer Stem Cells. Anticancer Res. 2015;35(12):6607-6614.

(6) 高橋可菜子,高橋俊文,太田 剛,小島原敬信,菊池憲明,冨田善彦,木村 理.再発婦人科悪性腫瘍に対して骨盤除臓術を施行した2例.2015;33(1):33-40

(7) 五十嵐秀樹,高橋俊文,堤 誠司,網田光善,高橋一広. 16歳の非交通性副角子宮を伴う単角子宮に対し腹腔鏡下手術を行った1例. 山形医学 2015;33(1):47-53

(8) 渡邉憲和,高橋俊文,永瀬 智. 後天性止血異常を合併しlow density lipoprotein アフェレーシス施行時および子宮頸部生検時に止血困難な性器出血を来した家族性高コレステロール血症合併子宮頸癌の一例. 山形医学 2015;33(2):97-10

(1) Takano T, Otsuki T, Tokunaga H, Toyoshima M, Utsunomiya H, Nagase S, Niikura H, Ito K, Yaegashi N, Yamada H, Tase T, Kagabu M, Shoji T, Sugiyama T, Sato N, Fujimoto T, Terada Y, Nakahara K, Kurachi H, Yokoyama Y, Mizunuma H, Soeda S, Nishiyama H, Matsumoto T, Sato S, Shimada M, Kigawa J. Paclitaxel-carboplatin for advanced or recurrent carcinosarcoma of the uterus: the Japan Uterine Sarcoma Group and Tohoku Gynecologic Cancer Unit Study. Int J Clin Oncol. 2014;19(6):1052-1058

(2) Yamatani H, Takahashi K, Yoshida T, Soga T, Kurachi H. Differences in the fatty acid metabolism of visceral adipose tissue in postmenopausal women. Menopause 2014;21(2):170-176

(3) Yokoyama Y, Futagami M, Watanabe J, Sato N, Terada Y, Miura F, Sugiyama T, Takano T, Yaegashi N, Kojimahara T, Kurachi H, Nishiyama H, Fujimori K, Tase T, Mizunuma H. Redistribution of resistance and sensitivity to platinum during the observation period following treatment of epithelial ovarian cancer. Mol Clin Oncol 2014;2:212-218

(4) Takehara I, Takahashi T, Hara S, Matsuo K, Igarashi H, Kurachi H. Dizygotic twin pregnancy after single embryo transfer:a case report and review of the literature.J Assist Reprod Genet 2014;31(4):443-446

(5) Obata M, Tsutsumi S, Makino S, Takahashi K, Watanabe N, Yoshida T, Tamiya G, Kurachi H. Whole-exome sequencing confirmation of a novel heterozygous mutation in RUNX1 in a pregnant woman with platelet disorder. Platelets 2014;22:1-6

(6) Liu Z, Yamanouchi K, Ohta T, Matsumura S, Seino M, Shridhar V, Takahashi T, Takahashi K, Kurachi H. High levels of wilms’tumor 1(WT1) expression were associated with aggressive clinical features in ovarian cancer. Anticancer Res 2014;34(5):2331-2340

(7) Ishida H, Takahashi K, Kurachi H. Uterine prolapse during late pregnancy in a nulliparous woman: a case report. Int Urogynecol J 2014;25(12):1739-1740

(8) Takahashi T, Igarashi H, Hara S, Amita M, Matsuo K, Hasegawa A, Kurachi H. Brachial-to-ankle pulse wave velocity as an independent prognostic factor for ovulatory response to clomiphene citrate in women with polycystic ovary syndrome. J Ovarian Res 2014;7:74

(9) Mabuchi S, Matsumoto Y, Kawano M, Minami K, Seo Y, Sasano T, Takahashi R, Kuroda H, Hisamatsu T, Kakigano A, Hayashi M, Sawada K, Hamasaki T, Morii E, Kurachi H, Matsuura N, Kimura T. Uterine cervical cancer displaying tumor-related leukocytosis: a distinct clinical entity with radioresistant feature. 2014;106(7).

(10) Seino M, Okada M, Shibuya K, Seino S, Suzuki S, Ohta T, Kurachi H, Kitanaka C. Requirement of JNK signaling for self-renewal and tumor-initiating capacity of ovarian cancer stem cells. Anticancer Res. 2014;(9):4723-4731.

(11) Yamanouchi K, Ohta T, Liu Z, Oji Y, Sugiyama H, Shridhar V, Matsumura S, Takahashi T, Takahashi K, Kurachi H. The Wilms’ Tumor Gene WT1 – 17AA/- KTS Splice Variant Increases Tumorigenic Activity Through Up-Regulation of Vascular Endothelial Growth Factor in an In Vivo Ovarian Cancer Model. Transl Oncol. 2014;7(5):580-589.

(12) Sato N, Takagi K, Suzuki T, Miki Y, Tanaka S, Nagase S, Warita H, Fukudo S, Sato F, Sasano H, Ito K: Immunolocalization of corticotropin-releasing hormone (CRH) and its receptors (CRHR1 and CRHR2) in human endometrial carcinoma: CRHR1 as a potent prognostic factor. Int J Gynecol Cancer. 2014;24(9):1549-1557.

(13) 高橋俊文,五十嵐秀樹,原 周一郎,網田光善,松尾幸城,倉智博久.腹腔鏡併用による卵管鏡下卵管形成術の治療成績および術後妊娠に関する予後因子の検討.山形医学 2014

(14) 鈴木聡子,堤 誠司,小幡美由紀,吉田隆之,倉智博久.MCA-PSV測定により児を救命し得た臍帯潰瘍合併上部消化管閉鎖の1例.日本周産期・新生児医学会雑誌 2014;50(1):343-346

(15) 長谷川歩美,太田 剛,倉智博久. 子宮頸部神経内分泌癌6例の解析. 臨床婦人科産科 2014;68(1):165-170

(1) Amita M, Adachi K, Alexenko AP, Sinha S, Schust DJ, Schulz LC, Roberts RM, Ezashi T. Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4. Proc Natl Acad Sci USA 2013;110(13):E1212-1221

(2) Ikeda M, Takahashi T, Kurachi H. Spontaneous perforation of pyometra: a report of seven cases and literature of the review. Gynecol Obstet Invest 2013;75(4):243-249

(3) Noda-Seino H, Sawada K, Hayakawa J, Ohyagi-Hara C, Mabuchi S, Takahashi K, Nishio Y, Sakata M, Kurachi H, Kimura T. Estradiol and raloxifene induce the proliferation of osteoblasts through G-protein-coupled receptor GPR30. J Endocrinol Invest 2013;36(1):21-27

(4) Yamatani H, Takahashi K, Yoshida T, Takata K, Kurachi H. Association of estrogen with glucocorticoid levels in visceral fat in postmenopausal women. Menopause 2013;20(4):437-442

(5) Ohyagi-Hara C, Sawada K, Kamiura S, Tomita Y, Isobe A, Hashimoto K, Kinose Y, Mabuchi S, Hisamatsu T, Takahashi T, Kumasawa K, Nagata S, Morishige K, Lengyel E, Kurachi H, Kimura T. miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin α5 expression. Am J Pathol 2013;182(5):1876-1889

(6) Yamatani H, Takahashi K, Yoshida T, Soga T, Kurachi H. Differences in the fatty acid metabolism of visceral adipose tissue in postmenopausal women. Menopause 2014;21(2):170-176

(7) Matsumura S, Ohta T, Takahashi T, Takahashi K, Yamazaki T, Kurachi H. Non-sex cord-stromal ovarian tumors frequently produce and secrete estrogen in postmenopausal women:impact on bone metabolism and abnormal endometrial histology. J Clin Endocrinol Metab 2013;98(7):2775-2782

(8) Yokoyama Y, Futagami M, Fujimoto T, Terada Y, Takatori E, Sugiyama T, Otsuki T, Yaegashi N, Kojimahara T, Kurachi H, Nishiyama H, Fujimori K, Tase T, Mizunuma H. Investigation of the clinicopathological features of fallopian tube malignancy. Oncol Rep 2013;30(1):79-84

(9) Hisamatsu T, Mabuchi S, Matsumoto Y, Kawano M, Sasano T, Takahashi R, Sawada K, Ito K, Kurachi H, Schilder RJ, Testa JR, Kimura T. Potential role of mTORC2 as a therapeutic target in clear cell carcinoma of the ovary. Mol Cancer Ther 2013;12(7):1367-1377

(10) Kojimahara T, Nakahara K, Takano T, Yaegashi N, Nishiyama H, Fujimori K, Sato N, Terada Y, Tase T, Yokoyama Y, Mizunuma H, Shoji T, Sugiyama T, Kurachi H. Yolk sac tumor of the ovary: A retrospective multicenter study of 33 Japanese women by Tohoku Gynecologic Cancer Unit (TGCU). Tohoku J Exp Med 2013;230(4):211-217

(11) Wakabayashi A, Sawada K, Nakayama M, Toda A, Kimoto A, Mabuchi S, Kinose Y, Nakamura K, Takahashi K, Kurachi H, Kimura T. Targeting interleukin-6 receptor inhibits preterm delivery induced by inflammation. Mol Hum Reprod 2013;19(11):718-726

(12) Matsuo K, Takahashi T, Igarashi H, Hara S, Amita M, Kurachi H. Effects of different trehalose concentrations in a warming medium on embryo survival and clinical outcomes in vitrified human embryos. Gynecol Obstet Invest 2013;76(4):214-220

(13) Hara S, Takahashi T, Amita M, Matsuo K, Igarashi H, Kurachi H. Pioglitazone counteracts the tumor necrosis factor-α inhibition of follicle-stimulating hormone-induced follicular development and estradiol production in an in vitro mouse preantral follicle culture system. J Ovarian Res 2013;6(1):69

(14) Kato N, Hayasaka T, Takeda J, Osakabe M, Kurachi H. Ovarian tumors with functioning stroma: a clinicopathologic study with special reference to serum estrogen level, stromal morphology, and aromatase expression. Int J Gynecol Pathol 2013;32(6):556-561

(1) Ohta T, Takahashi T, Shibuya T, Amita M, Henmi N, Takahashi K, Kurachi H.Inhibition of the Rho/ROCK pathway enhances the efficacy of cisplatin through the blockage of hypoxia-inducible factor-1α in human ovarian cancer cells. Cancer Biol Ther 2012;13(1):25-33

(2) Tsutsumi S, Maekawa A, Obata M, Morgan T, Robertson SP, Kurachi H. A case of boomerang dysplasia with a novel causative mutation in filamin B: identification of typical imaging findings on ultrasonography and 3D-CT imaging. Fetal Diagn Ther 2012;32:216-220

(3) Yamamoto S, Tsuda H, Shimazaki H, Takano M, Yoshikawa T, Kuzuya K, Tsuda H, Kurachi H, Kigawa J, Kikuchi Y, Sugiyama T, Matsubara O. Histological grading of ovarian clear cell adenocarcinoma: proposal for a simple and reproducible grouping system based on tumor growth architecture. Int J Gynecol Pathol 2012;31(2):116-124.

(4) Daniel PB, Morgan T, Alanay Y, Bijlsma E, Cho TJ, Cole T, Collins F, David A, Devriendt K, Faivre L, Ikegawa S, Jacquemont S, Jesic M, Krakow D, Liebrecht D, Maitz S, Marlin S, Morin G, Nishikubo T, Nishimura G, Prescott T, Scarano G, Shafeghati Y, Skovby F, Tsutsumi S, Whiteford M, Zenker M, Robertson SP. Disease-associated mutations in the actin-binding domain of filamin B cause cytoplasmic focal accumulations correlating with disease severity. Hum Mutat 2012;33(4):665-673

(5) Ohta T, Ohmichi M, Shibuya T, Takahashi T, Tsutsumi S, Takahashi K, Kurachi H. Gefitinib (ZD1839) increases the efficacy of cisplatin in ovarian cancer cells. Cancer Biol Ther 2012;13(6):408-416

(6) 成味 恵,前川絢子,吉田隆之,堤 誠司,倉智博久. 妊娠17週でHELLP症候群を発症した抗リン脂質抗体症候群合併妊娠. 日本周産期・新生児医学会雑誌 2012;48(1):136-141

(7) 清野 学,高橋俊文,倉智博久. 婦人科がん周術期における術後抗凝固療法の症候性肺血栓塞栓症予防に関する検討-静脈血栓塞栓症高リスク患者における検討-. 日本血栓止血学会誌 2012;23(3):280~287

(8) 椎名有二,早坂典子,清野 学,漆山敬子,前川絢子,網田光善,須藤 毅,堤 誠司,倉智博久. 穿通胎盤となった峡部頸管妊娠の1例-着床部位についての初期画像診断. 産婦人科の実際 2012;61(6):937-941

(9) 松村創平,太田 剛,水谷雅臣,蜂谷 修,木村 理,菅井幸雄,高橋一広,倉智博久. 婦人科腫瘍との鑑別が困難であったGISTの2例. 臨床婦人科産科 2012;66(9):799-802

(1) Takahashi K, Piao S, Yamatani H, Du B, Yin L, Ohta T, Kawagoe J, Takata K, Tsutsumi S, Kurachi H. Estorogen induces neurite outgrowth via Rho family GTPases in neuroblastoma cells. Mol Cell Neurosci 2011;48(3):217-224

(2) Yamamoto S, Tsuda H, Shimazaki H, Takano M, Yoshikawa T, Kuzuya K, Tsuda H, Kurachi H, Kigawa J, Kikuchi Y, Sugiyama T. Clear cell adenocarcinoma with a component of poorly differentiated histology: a poor prognostic subgroup of ovarian clear cell adenocarcinoma. Int J Gynecol Path 2011;30(5):431-441

(3) Hara S, Takahashi T, Amita M, Igarashi H, Tsutsumi S, Kurachi H. Bezafibrate restores the inhibition of FSH-induced follicular development and steroidogenesis by tumor necrosis factor-alpha through peroxisome proliferator-activated receptor-gamma pathway in an in vitro mouse preantral follicle culture. Biol Reprod 2011;85(5):895-906

(4) Mabuchi S, Hisamatsu H, Kawase C, Hayashi M, Sawada K, Mimura K, Takahashi K, Takahashi T, Kurachi H, Kimura T. The activity of trabectedin as a single agent or in combination with everolimus for clear cell carcinoma of the ovary. Clin Cancer Res 2011;17(13):4462-4473

(5) Yoshida T, Takahashi K, Yamatani H, Takata K, Kurachi H. Impact of surgical menopause on lipid and bone metabolism. Climacteric 2011;14(4):445-452

(6) Shoji T, Takatori E, Omi H, Kumagai S, Yoshizaki A, Yokoyama Y, Mizunuma H, Fujimoto T, Takano T, Yaegashi N, Tase T, Nakahara K, Kurachi H, Nishiyama H, Sugiyama T. Phase Ⅱ clinical study of the combination chemotherapy regimen of irinotecan plus oral etoposide for the treatment of recurrent ovarian cancer. (Tohoku Gynecologic Cancer Unit 101 Group Study) Int J Gynecol Cancer 2011;21(1):44-50

(7) Yamamoto S, Kasajima A, Takano M, Yaegashi N, Fujiwara H, Kuzuya K, Kigawa J, Tsuda H, Kurachi H, Kikuchi Y, Sugiyama T, Tsuda H, Moriya T. Validation of the histologic grading for ovarian clear cell adenocarcinoma: a retrospective multi-institutional study by the Japan clear cell carcinoma study group. Int J Gynecol Pathol 2011;30(2):129-138

(8) Kojimahara T, Nakahara K, Shoji T, Sugiyama T, Takano T, Yaegashi N, Yokoyama Y, Mizunuma H, Tase R, Satou H, Tanaka T, Motoyama T, Kurachi H. Identifying prognostic factors in Japanese women with pseudomyxoma peritonei: a retrospective clinico-pathological study of the Tohoku Gynecologic Cancer unit. Tohoku J Exp Med 2011;223(2):91-96

(9) Oishi A, Takahashi K, Ohmichi M, Mochizuki Y, Inaba N, Kurachi H. Role of glucocorticoid receptor in the inhibitory effect of medoroxyprogesterone acetate on the estrogen-induced eNOS phosphorylation in human umbilical vein endothelial cells. Fertil Steril 2011;95(3):1168-1170

Roles of prostaglandins during oocyte maturation: lessons from knockout mice. Takahashi T, Igarashi H, Amita M, Hara S, Kurachi H. J Mamm Ova Res. 2010 27(1):11-20

Roles of prostaglandins during oocyte maturation: lessons from knockout mice. Takahashi T, Igarashi H, Amita M, Hara S, Kurachi H. J Mamm Ova Res. 2010 27(1):11-20

Histopathological prognostic factors predicting para-aortic lymph node metastasis in patients with endometrioid uterine cancer. Karube Y, Fujimoto T, Takahashi O, Nanjyo H, Mizunuma H, Yaegashi N, Sugiyama T, Kurachi H, Sato A, Tanaka T. Gynecol Oncol. 2010 Aug 1;118(2):151-4.

Effect of dienogest on estrogen-induced nitric oxide production in human umbilical vein endothelial cells and endothelium-dependent vasodilatation in postmenopausal women. Henmi N, Takahashi K, Amita M, Takata K, Ohta T, Tsutsumi S, Takahashi T, Kurachi H. Menopause. 2010 May-Jun;17(3):615-21.

Usefulness of bezafibrate for ovulation induction in clomiphene citrate-resistant polycystic ovary syndrome patients with dyslipidemia: a prospective pilot study of seven cases. Hara S, Takahashi T, Amita M, Igarashi H, Kurachi H. Gynecol Obstet Invest. 2010;70(3):166-72. Epub 2010 Jun 16.

Molecular mechanism of the inhibition of estradiol-induced endometrial epithelial cell proliferation by clomiphene citrate. Amita M, Takahashi T, Tsutsumi S, Ohta T, Takata K, Henmi N, Hara S, Igarashi H, Takahashi K, Kurachi H. Endocrinology. 2010 Jan;151(1):394-405. Epub 2009 Nov 24.

Successful management of a large fetal mediastinal teratoma complicated by hydrops fetalis. Takayasu H, Kitano Y, Kuroda T, Morikawa N, Tanaka H, Fujino A, Muto M, Nosaka S, Tsutsumi S, Hayashi S, Sago H. J Pediatr Surg. 2010 Dec;45(12):e21-4.

The Akt and ERK activation by platinum-based chemotherapy in ovarian cancer is associated with favorable patient outcome. Ohta T, Isobe M, Takahashi T, Saitoh-Sekiguchi M, Motoyama T, Kurachi H. Anticancer Res. 2009 Nov;29(11):4639-47.

Endometrioid uterine cancer: histopathological risk factors of local and distant recurrence. Fujimoto T, Nanjyo H, Fukuda J, Nakamura A, Mizunuma H, Yaegashi N, Sugiyama T, Kurachi H, Sato A, Tanaka T. Gynecol Oncol. 2009 Feb;112(2):342-7. Epub 2008 Dec 4.

Poor embryo development in mouse oocytes aged in vitro is associated with impaired calcium homeostasis. Takahashi T, Igarashi H, Kawagoe J, Amita M, Hara S, Kurachi H. Biol Reprod. 2009 Mar;80(3):493-502. Epub 2008 Nov 26.